Check Carefully (1)pentobarbital will lower the extent or influence of benzhydrocodone/acetaminophen by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Caution when discontinuing CYP3A4 inducers which might be coadministered with benzhydrocodone (prodrug of hydrocodone); plasma concentrations of hydrocodone